{"id":477,"date":"2025-09-08T14:10:04","date_gmt":"2025-09-08T11:10:04","guid":{"rendered":"https:\/\/en.iepor.site\/?page_id=477"},"modified":"2026-03-04T22:41:21","modified_gmt":"2026-03-04T19:41:21","slug":"department-of-ecology-and-sorption-toxicology","status":"publish","type":"page","link":"https:\/\/en.iepor.site\/?page_id=477","title":{"rendered":"Department of Ecology and Sorption Toxicology"},"content":{"rendered":"\n<p class=\"has-medium-font-size wp-block-paragraph\">\n<em><strong>Head:<\/strong><\/em>&nbsp;<em>Veronika V. Sarnatska<\/em>\n<br>\n<em><strong>Degree, academic title:<\/strong><\/em>&nbsp;<em>Dr. Sci. (Biol.), Senior Researcher<\/em>\n<br>\n<em><strong>Tel:&nbsp;<\/strong><\/em><em>+38 (044) 257-90-55<\/em>\n<br>\n<em><strong>E-mail<\/strong><\/em><em><strong>:<\/strong><\/em><em>&nbsp;<a href=\"mailto:vsnikavera@gmail.com\">vsnikavera@gmail.com<\/a><\/em>\n<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" style=\"font-size:22px\"><strong>Research Areas<\/strong><\/h3\n\n\n\n<p class=\"wp-block-paragraph\">Minimization of the impact of carcinogenic factors and toxins on the human and animal body by developing effective therapeutic approaches and tools using novel carbon sorbents;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Development of fundamental advancements in the theory of detoxification processes;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Study of the influence of nanostructured materials on the functioning of biological systems and the possibility of their use in medicine;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pathogenesis of side effects in healthy tissues of cancer patients due to radiation therapy, and search for modifiers of biological responses of normal tissues to therapeutic irradiation;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Determination of the maximum synergy patterns during the interaction of ionizing radiation with chemical toxic factors.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" style=\"font-size:22px\"><strong>Key words:<\/strong><\/h3\n\n\n\n<p class=\"wp-block-paragraph\">Radiotherapy and radiation complications, radiomitigators, oxidative stress, radiosensitivity, sorption detoxification, carbon sorbents, nanomaterials, endogenous intoxication, sorption therapy means, enterosorbents, application sorption materials, hemosorbents, chemotherapy side effects, chemosensitization<\/p>\n\n\n\n\n<button class=\"accordion-blog\">Research<\/button>\n<div class=\"panel-blog\">\n\n\n<p class=\"wp-block-paragraph\">Relevance and priority of fundamental scientific tasks are focused on two main areas: 1) Medical sorbents and nanomaterials in experimental therapy of systemic manifestations of cytostatic disease; 2) Radio-chemotherapy combined effects on genetic and metabolic changes in peripheral blood lymphocytes of cervical cancer patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">    \u2022 Exploration of highly activated carbon (HAC) enterosorbents for mitigating radiation effects, performing experiments with rats acutely irradiated with X-rays of sub-lethal dose (6.0 Gy);<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">    \u2022 Exploration of HAC for minimizing chemotherapy side effects and cancer progression (used either in granular form for enterosorption or in micronized form for intraperitoneal injections, performing experiments with rats);<\/p>\n\n\n \n<p class=\"wp-block-paragraph\">   \u2022 Exploration of CeO2 nanoparticles in combined suspensions with micronized HAC in terms of their ability to chemosensitize tumors and to further minimize chemotherapy side effects;<\/p>\n\n\n \n<p class=\"wp-block-paragraph\">   \u2022 Determination of radiosensitivity predictors in non-malignant cells of onco-gynecological patients exposed to therapeutic radiation, aiming to personalize the treatment modalities. <\/p>\n\n<\/div>\n\n\n\n\n\n<button class=\"accordion-blog\">Grants<\/button>\n<div class=\"panel-blog\">\n\n\n<p class=\"wp-block-paragraph\">Grant No. STV00003R2 of the Australian Academy of Science (Ukrainian-Australian Research Foundation): Title &#171;NMR study of phospholipase-D activity in erythrocytes: activation of morphological changes of the cell surface and transphosphorylation reactions.&#187; (03\u201305.2024)<\/p>\n\n\n<p class=\"wp-block-paragraph\">NATO \u2013 Science for Peace and Security, Programme Multi-Year Project Application, SPS Project No. G5683. (2020\u20132023)<\/p>\n\n\n<p class=\"wp-block-paragraph\">Horizon Marie Sk\u0142odowska-Curie Research and Innovation Staff Exchange project No. 737641: NanoMed \u2013Nanoporous and Nanostructured Materials for Medical Applications, No. 737641: NanoMed. Acronyme: NanoMed. (2016\u20132020)<\/p>\n\n\n<\/div>\n\n\n\n<button class=\"accordion-blog\">Conferences<\/button>\n<div class=\"panel-blog\">\n\n<p>\u2022 International Scientific Conference on Advances in Cell Biology, Microbiology, and Biotechnology (ISCACMB 2025), Lviv, Ukraine, June 12\u201313;<\/p>\n<p>\u2022 CYTO 2025 Congress of the International Society for Advancement of Cytometry (ISAC), Denver, CO, USA, May 31 \u2013 June 4, 2025;<\/p>\n<p>\u2022 5th International Scientific and Practical Conference \u201cProblems and Achievements of Modern Biotechnology\u201d, Kharkiv, Ukraine, March 28, 2025;<\/p>\n<p>\u2022 IEEE 14th International Conference \u201cNanomaterials: Application &#038; Properties\u201d, Riga, Latvia, September 8\u201313, 2024;<\/p>\n<p>\u2022 Scientific and Practical Anniversary Conference of the Ukrainian Society of Radiation Oncologists with International Participation \u201cCurrent Issues of Radiation Oncology in Ukraine\u201d, Rivne, Ukraine, August 21\u201322, 2024;<\/p>\n<p>\u2022 XXI International Conference on Inorganic Chemistry Ukraine (XXI ICICU), Uzhhorod, Ukraine, June 3\u20136, 2024;<\/p>\n<p>\u2022 International Scientific Symposium: \u201cErbe der europ\u00e4ischen Wissenschaft \/ Heritage of European science \u20182024\u201d, Karlsruhe, Germany, February 28, 2024;<\/p>\n<p>\u2022 IEEE 13th International Conference \u201cNanomaterials: Applications &#038; Properties\u201d , Bratislava, Slovakia, September 10\u201315, 2023;<\/p>\n<p>\u2022 8th Congress of the Radiobiological Society of Ukraine, Zhytomyr, Ukraine, August 21\u201325, 2023;<\/p>\n<p>\u2022 Scientific and Practical Conference of the Ukrainian Society of Radiation Oncologists with International Participation \u201cCurrent Issues of Radiation Oncology in Ukraine\u201d, Uzhhorod, Ukraine, August 22\u201323, 2023;<\/p>\n<p>\u2022 19th North-Baltic Conference on Biomedical Engineering and Medical Physics held in Liepaja, Latvia, June 12\u201314, 2023;<\/p>\n<p>\u2022 CYTO 2023 Congress of the International Society for Advancement of Cytometry (ISAC) held in Montreal, Canada, May 20\u201324, 2023;<\/p>\n<p>\u2022 3rd International Scientific and Practical Internet Conference, Dnipro, Ukraine, March 2\u20133, 2023;<\/p>\n<p>\u2022 5th Scientific\/Practical Internet Conference with International Participation \u201cMechanisms of Development of Pathologic Processes and Diseases, and Their Pharmacological Correction\u201d, Kharkiv, Ukraine, November 17, 2022;<\/p>\n<p>\u2022 All-Ukrainian Conference with International Participation &#171;Theory and Practice of Modern Morphology&#187;, Dnipro, Ukraine , November 9\u201311, 2022;<\/p>\n<p>\u2022 All-Ukrainian Conference with International Participation \u201cChemistry, Physics and Technology of Surface\u201d, Kyiv, Ukraine, October 19\u201320, 2022;<\/p>\n<p>\u2022 Scientific and Practical Conference of the Ukrainian Society of Radiation Oncologists with International Participation &#171;Current Issues of Radiation Oncology in Ukraine&#187;, Lviv, Ukraine, September 21\u201322, 2022;<\/p>\n<p>\u2022 XVI International Scientific Conference \u201cOlvian Forum \u2013 2022: Strategies of the Countries of the Black Sea Region in the Geopolitical Space\u201d, Mykolaiv, Ukraine, June 23\u201326, 2022;<\/p>\n<p>\u2022 XIV Congress of Oncologists and Radiologists of Ukraine, Kyiv, Ukraine, September 30 \u2013 October 2, 2021;<\/p>\n<p>\u2022 Annual Scientific Conference of the Institute for Nuclear Research of the National Academy of Sciences of Ukraine, Kyiv, Ukraine, September 27\u2013October 1, 2021;<\/p>\n<p>\u2022 VIII Congress of the Ukrainian Society of Radiation Oncologists, Kherson, Ukraine, September 21\u201323, 2021;<\/p>\n<p>\u2022 CYTO Virtual Interactive 2021 Congress of the International Society for Advancement of Cytometry (ISAC), June 7\u201310, 2021;<\/p>\n<p>\u2022 General Meeting of the National Academy of Medical Sciences of Ukraine with International Participation \u201cThirty-five years of the Chornobyl disaster: Current and Future Research on Radiological and Medical Consequences\u201d, Kyiv, Ukraine, April 14 \u201315, 2021;<\/p>\n<p>\u2022 VI All-Ukrainian Scientific and Practical Conference \u201cInnovative Entrepreneurship: Status and Development Prospects\u201d, Kyiv, Ukraine, March 29\u201330, 2021;<\/p>\n<p>\u2022 CYTO Virtual 2020 Congress of the International Society for Advancement of Cytometry (ISAC), August 4\u20135, 2020.<\/p>\n\n\n<\/div>\n\n\n\n<button class=\"accordion-blog\">Publications<\/button>\n<div class=\"panel-blog\">\n\n<p>\u2022 Domina E.A. Particularities of radiation carcinogenesis: history and facts. Chapter in monograph \u00abScientific thought development\u00bb, series \u00abEuropean Science\u00bb 2024, Book 31. Part 4, pp. 131\u2013141. Karlsruhe: ScientificWorld-NetAkhatAV. ISBN 978-3-98924-056-8. https:\/\/doi.org\/10.30890\/2709-2313.2024-31-00-026<\/p>\n<p>\u2022 Domina E.A. Radiation-induced instability of the human genome during low-dose irradiation. \u0421hapter in monograph \u00abHeritage of European science \u20182024\u00bb, \u0440p. 88\u2013101. Karlsruhe: ScientificWorld-NetAkhatAV. ISBN 978-3-98924-039-1. https:\/\/doi.org\/10.30890\/2709-2313.2024-27-00-015<\/p>\n<p>\u2022 Sarnatskaya V., Shlapa Y., Kolesnik D., Lykhova O., Klymchuk D., Solopan S., Lyubchyk S., Golovynska I., Qu J., Stepanov Y., Belous A. Bioactivity of cerium dioxide nanoparticles as a function of size and surface features. Biomater. Sci. 2024; 12(10):2689\u20132704. https:\/\/doi.org\/10.1039\/d3bm01900d<\/p>\n<p>\u2022 Shlapa Y., Siposova K., Sarnatskaya V., Drajnova M., Silvestre-Albero J., Lykhova O., Maraloiu V.-A., Solopan S., Molcan M., Musatov A., Belous A. Bioactive carbon@CeO composites as efficient antioxidants with antiamyloid and radioprotective potentials. ACS Appl. Bio Mater. 2024; 7(10):6749\u20136767. https:\/\/doi.org\/10.1021\/acsabm.4c00912<\/p>\n<p>\u2022 Gerashchenko B.I., Sarnatskaya V.V., Bardakhivska K.I. Analysis of the volume of bone marrow cell nuclei for assessment of cytostatic myelosuppression and its prevention by activated carbon. Oncology 2024; 26(2):120\u2013124. https:\/\/doi.org\/10.15407\/oncology.2024.02.120<\/p>\n<p>\u2022 Makovetska L.I., Domina E.A. Prospects of the use of melatonin in radiation therapy. Oncology 2024; 26(1):5\u201321. https:\/\/doi.org\/10.15407\/oncology.2024.01.005<\/p>\n<p>\u2022 Ivankova V.S., Domina E.A., Khrulenko T.V., Makovetska L.I., Baranovska L.M., Glavin O.A. Prediction of radiation complications by determining the blood oxidation processes in cervical cancer patients under chemoradiotherapy. Ukr. J. Radiol. Oncol. 2024; 32(1):56\u201369. https:\/\/doi.org\/10.46879\/ukroj.1.2024.56-69<\/p>\n<p>\u2022 Gerashchenko B.I., Sarnatskaya V.V., Bardakhivska K.I., Sydorenko O.S., Kolesnik D.L., Klymchuk D.O. Myeloprotection with activated carbon in doxorubicin-treated rats. Heliyon 2023; 9(7):e18414. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e18414<\/p>\n<p>\u2022 Domina E.A. Kopylenko O.L. Chekhun V.F. Evaluation of current factors of radiation-associated carcinogenesis. Exp. Oncol. 2023; 45(2):15\u201324. https:\/\/doi.org\/10.15407\/exp-oncology.2023.02.151<\/p>\n<p>\u2022 Glavin O.A., Domina E.A., Ivankova V.S., Mikhailenko V.M., Makovetska L.I., Khrulenko T.V., Druzhyna M.O. Intensity of oxidative processes in blood and level of apoptosis in blood lymphocytes in radiologists\/x-ray technologies exposed to small doses of ionizing radiation. Probl. Radiat. Med. Radiobiol. 2023; 28:191\u2013205. https:\/\/radiationproblems.org.ua\/28_2023\/Book_NRCRM_2023_11.pdf<\/p>\n<p>\u2022 Ivankova V.S., Domina E.A., Khrulenko T.V., Baranovska L.M., Glavin O.A. Role of contemporary imaging methods in radiotherapy planning and monitoring of gynecological cancer patients (review). Probl. Radiat. Med. Radiobiol. 2023; 28:486\u2013503. https:\/\/radiationproblems.org.ua\/28_2023\/Book_NRCRM_2023_32.pdf<\/p>\n<p>\u2022 Sarnatskaya V., Shlapa Y., Lykhova A., Brieieva O., Prokopenko I., Sidorenko A., Solopan S., Kolesnik D., Belous A., Nikolaev V. Structure and biological activity of particles produced from highly activated carbon adsorbent. Heliyon 2022; 8(3):e09163. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e09163<\/p>\n<p>\u2022 Shlapa Y., Solopan S., Sarnatskaya V., Siposova K., Garcarova K., Veltruska V., Timashkov I., Lykhova A., Kolesnik D., Musatov A., Nikolaev V., Belous A. Cerium dioxide nanoparticles synthesized via precipitation at constant pH: Synthesis, physical-chemical and antioxidant properties. Colloids Surf. B Biointerfaces 2022; 220:112960. https:\/\/doi.org\/10.1016\/j.colsurfb.2022.112960<\/p>\n<p>\u2022 Mikhailenko V.M., Domina E.A., Ivankova V.S., Makovetska L.I., Glavin O.A., Khrulenko T.V. Features of oxidative metabolism and genetic disorders in peripheral blood lymphocytes of patients with primary cervical cancer. Exp. Oncol. 2022; 44(3):227\u2013233. https:\/\/doi.org\/10.32471\/exp-oncology.2312-8852.vol-44-no-3.18486<\/p>\n<p>\u2022 Domina E.A., Kopylenko O.L. Role of radioprotectors in minimization of stochastic effects of radiation incidents. Exp. Oncol. 2022; 44(3):186\u2013189. https:\/\/doi.org\/10.32471\/exp-oncology.2312-8852.vol-44-no-3.18530<\/p>\n<p>\u2022 Grinevich Y.A., Domina E.A. Immune and cytogenetic effects of densely and sparsely ionizing radiation. Kyiv: Publ. House \u201cAvicena\u201d, 2021, p. 384. ISBN 978-617-7597-35-2.<\/p>\n<p>\u2022 Gerashchenko B.I., Nikolaev V.G. Tackling the acute radiation syndrome: Hemoperfusion with activated carbon revisited. Med. Hypotheses 2021; 146:110430. https:\/\/doi.org\/10.1016\/j.mehy.2020.110430<\/p>\n<p>\u2022 Sakhno L.A., Babenko L.P., Lazarenko L.M., Korotych V.G., Sarnatskaya V.V., Snezhkova E.A., Spivak M.Y., Nikolaev V.G. Efficacy of dispersed fibrous carbon sorbent in treatment of malignant fungating wounds. Exp. Oncol. 2021; 43(4):359\u2013364. https:\/\/doi.org\/10.32471\/exp-oncology.2312-8852.vol-43-no-4.16757<\/p>\n<p>\u2022 Ivankova V.S., Domina E.A., Khrulenko T.V., Makovetska L.I., Hrinchenko O.O., Baranovska L.M. Effects of brachytherapy on cytogenetic parameters and oxidative status in peripheral blood lymphocytes of gynecologic cancer patients. Exp. Oncol. 2021; 43(3):242\u2013246. https:\/\/doi.org\/10.32471\/exp-oncology.2312-8852.vol-43-no-3.16514<\/p>\n<p>\u2022 Sarnatskaya V., Shlapa Y., Yushko L., Shton I., Solopan S., Ostrovska G., Kalachniuk L., Negelia A., Garmanchuk L., Prokopenko I., Khudenko N., Maslenny V., Bubnovskaya L., Belous A., Nikolaev V. Biological activity of cerium dioxide nanoparticles. J Biomed Mater Res. 2020; 108(8):1703\u20131712. https:\/\/doi.org\/10.1002\/jbm.a.36936<\/p>\n<p>\u2022 Sarnatskaya V., Mikhailenko V., Prokopenko I., Gerashchenko B., Shevchuk O., Yushko L., Glavin A., Makovetska L., Sakhno L., Sydorenko O., Kozynchenko O., Nikolaev V. The effect of two formulations of carbon enterosorbents on oxidative stress indexes and molecular conformation of serum albumin in experimental animals exposed to CCl4. Heliyon 2020; 6(1):e03126. https:\/\/doi.org\/10.1016\/j.heliyon.2019.e03126<\/p>\n<p>\u2022 Ivankova V.S., Domina E.A., Khrulenko T.V., Baranovska L.M., Hrinchenko O. O. Iridium-192 radiotherapy benefits in the management of gynecological tumors. Probl. Radiat. Med. Radiobiol. 2020; 25:569\u2013578. https:\/\/radiationproblems.org.ua\/25_2020\/NCRM_2020_Paper_36.pdf<\/p>\n<p>\u2022 Domina E. Expediency on using radiomitigators in radiation therapy of cancer patients. Journal of science. Lyon (France) 2020; 1(10):7\u201311. https:\/\/www.joslyon.com\/wp-content\/uploads\/2020\/08\/Lyon_10_1.pdf<\/p>\n\n<\/div>\n\n\n\n<button class=\"accordion-blog\">Patents<\/button>\n<div class=\"panel-blog\">\n\n<p>\u2022 International patent for invention WO2021\/194461 A1 \u201cThe method of production of a hemostatic agent and a hemostatic agent for major bleeding control\u201d by Komisarenko S.V., Nikolaev V.G., Platonova T.M., Dosenko V.Y., Sakhno L.O., Snezhkova E.O., Chernyshenko T.M., Korolova D.S., Chernyshenko V.O., Hornytska O.V., Korotych V.H. Publication date: 30.09.2021.<\/p>\n<p>\u2022 Patent of Ukraine for a utility model \u201cMethod of alleviating the negative effects of antitumor doxorubicin chemotherapy\u201d by Sarnatska V.V., Bardakhivska K.I., Pazyuk L.M., Gerashchenko B.I. Application number: u 2024 02662 dated 06.08.2024.<\/p>\n<p>\u2022 Patent of Ukraine for a utility model \u201cMethod of reducing the negative effects of antitumor chemotherapy\u201d by Sarnatska V.V., Pazyuk L.M., Gerashchenko B.I., Shlapa Y.Y. Application number: u 2024 04607 dated 27.09.2024.<\/p>\n<p>\u2022 Patent of Ukraine for a utility model \u201cMethod for producing carbon enterosorbents with increased mechanical stability\u201d by Sarnatska V.V., Pyatchanina T.V. Application number: u2024 04941 dated 15.10.2024.<\/p>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Head:&nbsp;Veronika V. Sarnatska Degree, academic title:&nbsp;Dr. Sci. (Biol.), Senior Researcher Tel:&nbsp;+38 (044) 257-90-55 E-mail:&nbsp;vsnikavera@gmail.com Research Areas<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":35,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-477","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/en.iepor.site\/index.php?rest_route=\/wp\/v2\/pages\/477","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/en.iepor.site\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/en.iepor.site\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/en.iepor.site\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/en.iepor.site\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=477"}],"version-history":[{"count":3,"href":"https:\/\/en.iepor.site\/index.php?rest_route=\/wp\/v2\/pages\/477\/revisions"}],"predecessor-version":[{"id":520,"href":"https:\/\/en.iepor.site\/index.php?rest_route=\/wp\/v2\/pages\/477\/revisions\/520"}],"up":[{"embeddable":true,"href":"https:\/\/en.iepor.site\/index.php?rest_route=\/wp\/v2\/pages\/35"}],"wp:attachment":[{"href":"https:\/\/en.iepor.site\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}