Relevance and priority of fundamental scientific tasks are focused on identifying the efficacy of the combines assessment of molecular and biological markers of both epithelial and stromal tumor components, which determine intravasation, invasion, and metastasis of cancer cells, and thus define the degree of malignancy.

• In-depth investigation of the relationship between steroid hormone receptor expression and phenotypic characteristics of the tumor microenvironment in endometrial and breast cancers, aimed at assessing their role in oncogenesis

• Identification of novel prognostic markers associated with aggressive tumor progression in hormone-dependent cancers of the endometrium and breast

• Study of mechanisms of estrogen-mediated modulation of antitumor immunity as a potential basis for immunotherapy of hormone-sensitive tumors, focusing on the regulation of steroid hormone action in stromal microenvironmental cells

• Investigation of K-RAS/ATR/CHEK1 signaling pathways associated with replicative stress in the context of aneuploidy, high proliferative index, and tumor invasiveness, aimed at stratifying endometrial cancer patients at high risk of metastatic progression

Evaluation of serum microRNA-424-5p and microRNA-185-5p expression levels in patients with endometrioid endometrial carcinoma as potential non-invasive biomarkers for predicting tumor aggressiveness and disease monitoring

Targeted research program of the NAS of Ukraine “Role of genomic instability markers expression in endometrial cancer progression”, State Registration No. 0123U102507 (2023)

Targeted research project “Factors of replicative stress in the progression of endometrioid endometrial carcinoma”, State Registration No. 0122U001977 (2022)

• Transdisciplinary Conference “Measuring Quality of Life of Cancer Patients on the Pages of Experimental and Clinical Oncology Journals: Challenges and Opportunities”, Kyiv, October 3–4, 2024

• 2nd Congress of the Ukrainian Association of Cytopathologists “Potential of Morphological Methods in the Verification of Tumorous and Non-Tumorous Diseases at the Present Stage”, Kyiv, November 6–7, 2023

• 7th All-Ukrainian Scientific and Practical Conference, Dnipro, November 1–3, 2023

• 19th International Conference “Youth and Progress in Biology”, Lviv, April 26–28, 2023

• 7th All-Ukrainian Scientific and Practical Conference “Innovative Entrepreneurship: Current State and Development Prospects”, Kyiv: KNEU, May 30, 2022

• Molecular Analysis for Precision Oncology Virtual Congress, European Society for Medical Oncology (ESMO), October 7–9, 2021

• 14th Congress of Oncologists and Radiologists of Ukraine, dedicated to the 100th anniversary of the National Cancer Institute, Kyiv, Ukraine, September 30 – October 2, 2021

• Scientific and Practical Conference “Modern Oncology: From Fundamental Research to Novel Therapeutic Approaches”, Kyiv, October 12–13, 2021

• 1st and 3rd Scientific and Practical Online Conferences “Mechanisms of Development of Pathological Processes and Diseases and Their Pharmacological Correction”, Kharkiv, October 18, 2018, and November 19, 2020

1. Liubov Buchynska, Inna Gordiienko, Nadiia Glushchenko, Nataliia Iurchenko. The KRAS, ATR and CHEK1 expression levels in endometrial cancer are the risk factors predicting recurrence. PLoS One. 2024; 19(4):e0302075. https://doi.org/10.1371/journal.pone.0302075

2. Chekhun V., Zavelevich M., Philchenkov A., Lukianova N., Shlapatska L., Gluzman D. Identification of leukemic stem cells: Possible implication in targeted therapy of acute myeloid leukemia. In: Rezaei, N. (Ed.), Comprehensive Hematology and Stem Cell Research. US: Elsevier. 2024, Vol. 5, pp.344-353. Hardback ISBN: 9780443157172. https://www.researchgate.net/publication/377052753_Identification_of_Leukemic_Stem_Cells_Possible_Implication_in_Targeted_Therapy_of_Acute_Myeloid_Leukemia

3. Philchenkov A., Dubrovska A. Cancer stem cells as a therapeutic target: Current clinical development and future prospective. Stem Cells 2024; 42 (3): 173–199. https://doi.org/10.1093/stmcls/sxad092

4. Iurchenko NP, Nesina IP, Glushchenko NМ, Buchynska LG. Role of stromal microenvironment in the formation of invasive, angiogenic, and metastatic potential of endometrioid carcinoma of endometrium. Exp Oncol. 2023; 45(1):51-61. https://doi.org/10.15407/exp-oncology.2023.01.051

5. Buchynska LG, Brieieva OV, Nespriadko SV. Expression of hepatocyte growth factor and c-MET receptor in stromal fibroblasts and tumor cells of endometrial carcinoma. Exp Oncol. 2023; 45(1):79-87. https://doi.org/10.15407/exp-oncology.2023.01.079

6. Buchynska LG, Iurchenko NP, Nesina IP, Glushchenko NM. Validation of a panel of biomarkers associated with aggressive phenotype of endometrioid carcinoma of endometrium. Exp Oncol 2022; 44 (3):234-238. https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-3.18513

7. Shlapatska L, Gordiienko I, Polischuk A, Gluzman D. Profile of CD150 expression in bone marrow cells of patients with acute myeloid leukemia. Exp. Oncol. 2022; 44(3):198–207. https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-3.18307

8. Nesina I, Iurchenko N, Nespriadko S, Buchynska L. Twist expression and content of tumour-associated macrophages in endometrial carcinoma. Oncol Clin Pract 2021; 17(4):139-147. https://doi.org/10.5603/OCP.2021.0026

9. Buchynska LG, Movchan OM, Iurchenko NP. Expression of chemokine receptor CXCR4 on tumor cells and content of CXCL12+-fibroblasts in endometrioid carcinoma of the endometrium. Exp Оncol 2021; 43(2):135-141. https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-2.16240

10. Gordiienko IM, Lykhova OO, Shcherbina VM, Shlapatska LM. SLAMF1/CD150 expression and topology in prostate and breast cancer cell lines. Exp Oncol; 2021: 43 (4):312-316. https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-4.17010

11. Buchynska LG, Borykun TV, Iurchenko NP, Nespryadko SV, Nesina IP. Expression of microRNA in tumor cells of endmetrioid carcinoma of endometrium. Exp Оncol 2020; 42(4):289-294. https://doi.org/10.32471/exp-oncology.2312-8852.vol-42-no-4.15522

12. Buchynska LG, Glushchenko NM, Nesina IP, Brieieva OV, Iurchenko NP. Molecular phenotype of high-grade endometrioid carcinoma of the endometrium. Exp Оncol 2020; 42(4):300-305. https://doi.org/10.32471/exp-oncology.2312-8852.vol-42-no-4.15450

13. Gluzman DF, Zavelevych MP, Philchenkov AA, et al. Leukemia. Radiation. Chornobyl (Oncohematological Consequences of the Chornobyl Catastrophe). New York: Nova Science Publishers, Inc., 2020. 176 p. ISBN: 1536186996