Relevance and priority of fundamental scientific tasks are focused on two main areas: 1) Medical sorbents and nanomaterials in experimental therapy of systemic manifestations of cytostatic disease; 2) Radio-chemotherapy combined effects on genetic and metabolic changes in peripheral blood lymphocytes of cervical cancer patients.

• Exploration of highly activated carbon (HAC) enterosorbents for mitigating radiation effects, performing experiments with rats acutely irradiated with X-rays of sub-lethal dose (6.0 Gy);

• Exploration of HAC for minimizing chemotherapy side effects and cancer progression (used either in granular form for enterosorption or in micronized form for intraperitoneal injections, performing experiments with rats);

• Exploration of CeO2 nanoparticles in combined suspensions with micronized HAC in terms of their ability to chemosensitize tumors and to further minimize chemotherapy side effects;

• Determination of radiosensitivity predictors in non-malignant cells of onco-gynecological patients exposed to therapeutic radiation, aiming to personalize the treatment modalities.

Grant No. STV00003R2 of the Australian Academy of Science (Ukrainian-Australian Research Foundation): Title «NMR study of phospholipase-D activity in erythrocytes: activation of morphological changes of the cell surface and transphosphorylation reactions.» (03–05.2024)

NATO – Science for Peace and Security, Programme Multi-Year Project Application, SPS Project No. G5683. (2020–2023)

Horizon Marie Skłodowska-Curie Research and Innovation Staff Exchange project No. 737641: NanoMed –Nanoporous and Nanostructured Materials for Medical Applications, No. 737641: NanoMed. Acronyme: NanoMed. (2016–2020)

• International Scientific Conference on Advances in Cell Biology, Microbiology, and Biotechnology (ISCACMB 2025), Lviv, Ukraine, June 12–13;

• CYTO 2025 Congress of the International Society for Advancement of Cytometry (ISAC), Denver, CO, USA, May 31 – June 4, 2025;

• 5th International Scientific and Practical Conference “Problems and Achievements of Modern Biotechnology”, Kharkiv, Ukraine, March 28, 2025;

• IEEE 14th International Conference “Nanomaterials: Application & Properties”, Riga, Latvia, September 8–13, 2024;

• Scientific and Practical Anniversary Conference of the Ukrainian Society of Radiation Oncologists with International Participation “Current Issues of Radiation Oncology in Ukraine”, Rivne, Ukraine, August 21–22, 2024;

• XXI International Conference on Inorganic Chemistry Ukraine (XXI ICICU), Uzhhorod, Ukraine, June 3–6, 2024;

• International Scientific Symposium: “Erbe der europäischen Wissenschaft / Heritage of European science ‘2024”, Karlsruhe, Germany, February 28, 2024;

• IEEE 13th International Conference “Nanomaterials: Applications & Properties” , Bratislava, Slovakia, September 10–15, 2023;

• 8th Congress of the Radiobiological Society of Ukraine, Zhytomyr, Ukraine, August 21–25, 2023;

• Scientific and Practical Conference of the Ukrainian Society of Radiation Oncologists with International Participation “Current Issues of Radiation Oncology in Ukraine”, Uzhhorod, Ukraine, August 22–23, 2023;

• 19th North-Baltic Conference on Biomedical Engineering and Medical Physics held in Liepaja, Latvia, June 12–14, 2023;

• CYTO 2023 Congress of the International Society for Advancement of Cytometry (ISAC) held in Montreal, Canada, May 20–24, 2023;

• 3rd International Scientific and Practical Internet Conference, Dnipro, Ukraine, March 2–3, 2023;

• 5th Scientific/Practical Internet Conference with International Participation “Mechanisms of Development of Pathologic Processes and Diseases, and Their Pharmacological Correction”, Kharkiv, Ukraine, November 17, 2022;

• All-Ukrainian Conference with International Participation «Theory and Practice of Modern Morphology», Dnipro, Ukraine , November 9–11, 2022;

• All-Ukrainian Conference with International Participation “Chemistry, Physics and Technology of Surface”, Kyiv, Ukraine, October 19–20, 2022;

• Scientific and Practical Conference of the Ukrainian Society of Radiation Oncologists with International Participation «Current Issues of Radiation Oncology in Ukraine», Lviv, Ukraine, September 21–22, 2022;

• XVI International Scientific Conference “Olvian Forum – 2022: Strategies of the Countries of the Black Sea Region in the Geopolitical Space”, Mykolaiv, Ukraine, June 23–26, 2022;

• XIV Congress of Oncologists and Radiologists of Ukraine, Kyiv, Ukraine, September 30 – October 2, 2021;

• Annual Scientific Conference of the Institute for Nuclear Research of the National Academy of Sciences of Ukraine, Kyiv, Ukraine, September 27–October 1, 2021;

• VIII Congress of the Ukrainian Society of Radiation Oncologists, Kherson, Ukraine, September 21–23, 2021;

• CYTO Virtual Interactive 2021 Congress of the International Society for Advancement of Cytometry (ISAC), June 7–10, 2021;

• General Meeting of the National Academy of Medical Sciences of Ukraine with International Participation “Thirty-five years of the Chornobyl disaster: Current and Future Research on Radiological and Medical Consequences”, Kyiv, Ukraine, April 14 –15, 2021;

• VI All-Ukrainian Scientific and Practical Conference “Innovative Entrepreneurship: Status and Development Prospects”, Kyiv, Ukraine, March 29–30, 2021;

• CYTO Virtual 2020 Congress of the International Society for Advancement of Cytometry (ISAC), August 4–5, 2020.

• Domina E.A. Particularities of radiation carcinogenesis: history and facts. Chapter in monograph «Scientific thought development», series «European Science» 2024, Book 31. Part 4, pp. 131–141. Karlsruhe: ScientificWorld-NetAkhatAV. ISBN 978-3-98924-056-8. https://doi.org/10.30890/2709-2313.2024-31-00-026

• Domina E.A. Radiation-induced instability of the human genome during low-dose irradiation. Сhapter in monograph «Heritage of European science ‘2024», рp. 88–101. Karlsruhe: ScientificWorld-NetAkhatAV. ISBN 978-3-98924-039-1. https://doi.org/10.30890/2709-2313.2024-27-00-015

• Sarnatskaya V., Shlapa Y., Kolesnik D., Lykhova O., Klymchuk D., Solopan S., Lyubchyk S., Golovynska I., Qu J., Stepanov Y., Belous A. Bioactivity of cerium dioxide nanoparticles as a function of size and surface features. Biomater. Sci. 2024; 12(10):2689–2704. https://doi.org/10.1039/d3bm01900d

• Shlapa Y., Siposova K., Sarnatskaya V., Drajnova M., Silvestre-Albero J., Lykhova O., Maraloiu V.-A., Solopan S., Molcan M., Musatov A., Belous A. Bioactive carbon@CeO composites as efficient antioxidants with antiamyloid and radioprotective potentials. ACS Appl. Bio Mater. 2024; 7(10):6749–6767. https://doi.org/10.1021/acsabm.4c00912

• Gerashchenko B.I., Sarnatskaya V.V., Bardakhivska K.I. Analysis of the volume of bone marrow cell nuclei for assessment of cytostatic myelosuppression and its prevention by activated carbon. Oncology 2024; 26(2):120–124. https://doi.org/10.15407/oncology.2024.02.120

• Makovetska L.I., Domina E.A. Prospects of the use of melatonin in radiation therapy. Oncology 2024; 26(1):5–21. https://doi.org/10.15407/oncology.2024.01.005

• Ivankova V.S., Domina E.A., Khrulenko T.V., Makovetska L.I., Baranovska L.M., Glavin O.A. Prediction of radiation complications by determining the blood oxidation processes in cervical cancer patients under chemoradiotherapy. Ukr. J. Radiol. Oncol. 2024; 32(1):56–69. https://doi.org/10.46879/ukroj.1.2024.56-69

• Gerashchenko B.I., Sarnatskaya V.V., Bardakhivska K.I., Sydorenko O.S., Kolesnik D.L., Klymchuk D.O. Myeloprotection with activated carbon in doxorubicin-treated rats. Heliyon 2023; 9(7):e18414. https://doi.org/10.1016/j.heliyon.2023.e18414

• Domina E.A. Kopylenko O.L. Chekhun V.F. Evaluation of current factors of radiation-associated carcinogenesis. Exp. Oncol. 2023; 45(2):15–24. https://doi.org/10.15407/exp-oncology.2023.02.151

• Glavin O.A., Domina E.A., Ivankova V.S., Mikhailenko V.M., Makovetska L.I., Khrulenko T.V., Druzhyna M.O. Intensity of oxidative processes in blood and level of apoptosis in blood lymphocytes in radiologists/x-ray technologies exposed to small doses of ionizing radiation. Probl. Radiat. Med. Radiobiol. 2023; 28:191–205. https://radiationproblems.org.ua/28_2023/Book_NRCRM_2023_11.pdf

• Ivankova V.S., Domina E.A., Khrulenko T.V., Baranovska L.M., Glavin O.A. Role of contemporary imaging methods in radiotherapy planning and monitoring of gynecological cancer patients (review). Probl. Radiat. Med. Radiobiol. 2023; 28:486–503. https://radiationproblems.org.ua/28_2023/Book_NRCRM_2023_32.pdf

• Sarnatskaya V., Shlapa Y., Lykhova A., Brieieva O., Prokopenko I., Sidorenko A., Solopan S., Kolesnik D., Belous A., Nikolaev V. Structure and biological activity of particles produced from highly activated carbon adsorbent. Heliyon 2022; 8(3):e09163. https://doi.org/10.1016/j.heliyon.2022.e09163

• Shlapa Y., Solopan S., Sarnatskaya V., Siposova K., Garcarova K., Veltruska V., Timashkov I., Lykhova A., Kolesnik D., Musatov A., Nikolaev V., Belous A. Cerium dioxide nanoparticles synthesized via precipitation at constant pH: Synthesis, physical-chemical and antioxidant properties. Colloids Surf. B Biointerfaces 2022; 220:112960. https://doi.org/10.1016/j.colsurfb.2022.112960

• Mikhailenko V.M., Domina E.A., Ivankova V.S., Makovetska L.I., Glavin O.A., Khrulenko T.V. Features of oxidative metabolism and genetic disorders in peripheral blood lymphocytes of patients with primary cervical cancer. Exp. Oncol. 2022; 44(3):227–233. https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-3.18486

• Domina E.A., Kopylenko O.L. Role of radioprotectors in minimization of stochastic effects of radiation incidents. Exp. Oncol. 2022; 44(3):186–189. https://doi.org/10.32471/exp-oncology.2312-8852.vol-44-no-3.18530

• Grinevich Y.A., Domina E.A. Immune and cytogenetic effects of densely and sparsely ionizing radiation. Kyiv: Publ. House “Avicena”, 2021, p. 384. ISBN 978-617-7597-35-2.

• Gerashchenko B.I., Nikolaev V.G. Tackling the acute radiation syndrome: Hemoperfusion with activated carbon revisited. Med. Hypotheses 2021; 146:110430. https://doi.org/10.1016/j.mehy.2020.110430

• Sakhno L.A., Babenko L.P., Lazarenko L.M., Korotych V.G., Sarnatskaya V.V., Snezhkova E.A., Spivak M.Y., Nikolaev V.G. Efficacy of dispersed fibrous carbon sorbent in treatment of malignant fungating wounds. Exp. Oncol. 2021; 43(4):359–364. https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-4.16757

• Ivankova V.S., Domina E.A., Khrulenko T.V., Makovetska L.I., Hrinchenko O.O., Baranovska L.M. Effects of brachytherapy on cytogenetic parameters and oxidative status in peripheral blood lymphocytes of gynecologic cancer patients. Exp. Oncol. 2021; 43(3):242–246. https://doi.org/10.32471/exp-oncology.2312-8852.vol-43-no-3.16514

• Sarnatskaya V., Shlapa Y., Yushko L., Shton I., Solopan S., Ostrovska G., Kalachniuk L., Negelia A., Garmanchuk L., Prokopenko I., Khudenko N., Maslenny V., Bubnovskaya L., Belous A., Nikolaev V. Biological activity of cerium dioxide nanoparticles. J Biomed Mater Res. 2020; 108(8):1703–1712. https://doi.org/10.1002/jbm.a.36936

• Sarnatskaya V., Mikhailenko V., Prokopenko I., Gerashchenko B., Shevchuk O., Yushko L., Glavin A., Makovetska L., Sakhno L., Sydorenko O., Kozynchenko O., Nikolaev V. The effect of two formulations of carbon enterosorbents on oxidative stress indexes and molecular conformation of serum albumin in experimental animals exposed to CCl4. Heliyon 2020; 6(1):e03126. https://doi.org/10.1016/j.heliyon.2019.e03126

• Ivankova V.S., Domina E.A., Khrulenko T.V., Baranovska L.M., Hrinchenko O. O. Iridium-192 radiotherapy benefits in the management of gynecological tumors. Probl. Radiat. Med. Radiobiol. 2020; 25:569–578. https://radiationproblems.org.ua/25_2020/NCRM_2020_Paper_36.pdf

• Domina E. Expediency on using radiomitigators in radiation therapy of cancer patients. Journal of science. Lyon (France) 2020; 1(10):7–11. https://www.joslyon.com/wp-content/uploads/2020/08/Lyon_10_1.pdf

• International patent for invention WO2021/194461 A1 “The method of production of a hemostatic agent and a hemostatic agent for major bleeding control” by Komisarenko S.V., Nikolaev V.G., Platonova T.M., Dosenko V.Y., Sakhno L.O., Snezhkova E.O., Chernyshenko T.M., Korolova D.S., Chernyshenko V.O., Hornytska O.V., Korotych V.H. Publication date: 30.09.2021.

• Patent of Ukraine for a utility model “Method of alleviating the negative effects of antitumor doxorubicin chemotherapy” by Sarnatska V.V., Bardakhivska K.I., Pazyuk L.M., Gerashchenko B.I. Application number: u 2024 02662 dated 06.08.2024.

• Patent of Ukraine for a utility model “Method of reducing the negative effects of antitumor chemotherapy” by Sarnatska V.V., Pazyuk L.M., Gerashchenko B.I., Shlapa Y.Y. Application number: u 2024 04607 dated 27.09.2024.

• Patent of Ukraine for a utility model “Method for producing carbon enterosorbents with increased mechanical stability” by Sarnatska V.V., Pyatchanina T.V. Application number: u2024 04941 dated 15.10.2024.